Creatine Supplementation Studies
While creatine has many applications to individuals of all gender, age,
mental and physical abilities, this paper is written for young, healthy men who
are active in sports or exercise. I have not taken into account the numerous
studies done for children, the elderly and middle aged, or women when writing
this article. All data and studies used in this paper are in reference to
healthy men between the ages of 18-40, who participate in physical activity
several times a week, unless otherwise stated.
Furthermore, I am neither a doctor, nor a pharmacologist. The
information, views, and advice contained within this paper are for educational
purposes only. Do not attempt any exercise plan, diet plan, or radical lifestyle
change without first consulting with a physician. The material in this paper
should not be construed for medical advice. Neither creatine, nor the methods of
supplementation discussed within should be used to treat any condition or
disease, unless instructed by a doctor.
The compound creatine has been hyped by supplement companies and
demonized by the media, and without proper study in the field of supplement
pharmacology, Primary Care physicians cannot offer any relevant information to
the consumer. It is not surprising that there is much confusion over the safety
and effects of creatine.
Creatine is a naturally occurring substance in human and animal bodies.
It is synthesized and consumed on a daily basis (the human liver can combine the
amino acids Arginine, Glycine, and Methionine to synthesize creatine). The
average 160 lb (72.5 kg) person stores approx. 120 grams of creatine in their
body. 95-98% of that creatine is contained within muscle tissue, while the rest
is stored within other body organs (including brain, heart and liver).
Creatine works by replenishing ATP. ATP (adenosine tri-phosphate)
is an energy-containing compound. The body can break ATP into ADP (adenosine di-phosphate)
and inorganic phosphate. This reaction releases energy, which can be used by the
body to fuel explosive, short burst of strength. The metabolism of carbohydrates
and fats take longer to convert into a useable energy source, so ATP is the most
used energy source during these high intensity movements. There is only enough
ATP for 10-15 seconds of maximum exertion, however, and so the problem arises as
to how to free up more energy. ADP is itself useless as a source of energy,
until it regains a phosphate atom. Creatine phosphate (CP), the form of creatine
found mostly in muscles, reacts with ADP. The phosphate is freed from creatine
and bonds with ADP to create ATP.
This purpose of creatine has been known for some time, however the
benefits or downfalls of exogenous supplementation of creatine on physical
performance, especially in the area of sports and exercise, has long been
glorified, but up until the past few years never substantiated with hard
science. The ignorance of health care professionals has obfuscated the subject
of creatine supplementation, and for many people the only information they hear
is the half-truths, propaganda, and lies of the media and supplement companies.
Many of the claims put forth about creatine’s safety focus on the idea
that it may harm the kidneys and liver. This is false. Creatine does not harm
the liver5, 24, 49, 80, or the kidneys1, 5, 8, 24, 49, 64, 80.
Some of these claims stem from the idea that creatinine levels are increased
with creatine supplementation (creatinine being a byproduct of renal failure).
Creatinine, while sometimes slightly elevated, is always within normal and safe
levels when creatine is used according to recommended guidelines2, 24, 29,
49, 64, 71, 80. A deleterious effect on cholesterol and lipid values is
another popular argument by critics of the supplement. While not studied as much
as other areas of safety, limited studies have shown no effect2, 5,
or a positive effect of cholesterol4. Blood values during creatine
supplementation have also been shown to be normal19, 49, 71, 80, as
well as effects on mood51.
A common complaint among sports coaches and players is that creatine may
increase injury rates. Some people have claimed this is due to increased
musculoskeletal stiffness. No studies have reported any signs of increased
injury with concomitant creatine use, and at least one has even tested the claim
and shown that there are no negative musculoskeletal changes with creatine use75.
On the other side of the spectrum, there are many claims of performance
enhancement with creatine use. Increased muscle mass2, 19, 26, 35, 37, 61,
71 is one proven effect of creatine use. Enhanced anaerobic capacity and
strength has shown to be beneficially effected6, 9, 16, 19, 26, 27, 28, 33,
34, 37, 40, 41, 46, 51, 52, 56, 59, 60, 61, 65, 86 in all but one68
study. The overwhelming data supporting increased strength, and to a lesser
degree muscle mass, makes creatine a wonder supplement. There are, however, many
more benefits to creatine supplementation that puts this supplement a step above
all others. Conflicting data shows that creatine may9, 10, 23, 69, 70
increase aerobic performance, or have no effect28, 50, 67, even
though body mass increases. The fact that aerobic performance increases are
possible in spite of increased body mass means that individuals training for
endurance, speed and strength may benefit from creatine without risking negative
changes in performance. Sprinting, studied in its numerous forms, also shows
mixed results with regards to creatine. While some show no effect12, 15,
20, 42, 43, 53, 56, 63, 73 the majority of studies have shown marked
increases in performance13, 19, 25, 28, 36, 38, 44, 57, 58, 62, 66, 79, 82.
Isometric strength increases22 and isometric strength endurance21,
anticatabolic47 and antioxidant31 properties, jumping
improvements59, 75, exercise recovery77, 78, performance
in hot conditions79, and time to neuromuscular fatigue81
are some of the other strength and endurance related benefits observed in some
of the studies. These benefits also come with another bonus: body fat percentage
has been shown to not change2, 61, 71 or decrease51 in
several studies that looked at body composition.
Creatine may also assist injured individuals who are recovering from
major injuries. After non-use and atrophy, creatine may increase GLUT-4 protein
concentration and translocation at cell membranes30 as well as
muscular performance recovery55. The intracellular water retention
creatine creates11, 26 may also help maintain an anabolic environment
and allow extra nutrient and glycogen to be stored in the recovering muscle.
Even though creatine has been show in some studies to have no effect on hormone
levels45, 49, one study studying Growth Hormone (GH) specifically has
shown an increase (within high normal levels) of GH with creatine use. GH has
anabolic properties, as well as healing properties, and this may be another
benefit of using creatine to help speed recovery from an injury. Another benefit
to individuals recovering from injury, and those that aren't, is that creatine
may stimulate satellite cell differentiation32, which may increase
muscle size and help heal injuries.
Creatine is also synergistic with many other substances. Creatine has
shown positive effects with pyruvate3, whey protein17,
caffeine18, carbohydrates34, 52, 74, l-glutamine37,
and magnesium72. Creatine stacked with HMB has produced good results48,
as well as no results14.
The dosing of creatine has also come into suspect since several animal
studies with ultra high doses of creatine produced creatine receptor down
regulation after several weeks of use. Considering these studies used extremely
high doses of creatine, and with at least one study showing no down regulation
with continued use in humans39, it appears now that cycling creatine
is not needed to keep your gains. Loading creatine in several small portions
throughout the day has given the best results and shown the most saturation of
the muscle amino acid pool with creatine76, and may be the best way
to take it during the loading phase.
Hopefully the stigma of creatine being a deadly drug that destroys
organs, increases injuries and increases fat will go away now that there are so
many studies showing the positive effects and lack of negative effects with
J.R., Francaux, M.,
Adverse effects of creatine supplementation: fact or fiction? Sports
Medicine (Auckland, N.Z.) 30 (3) 155-170 2000
J.S., Duncan, N.D., Mazzetti, S.A., Putukian, M., Gomez, A.L., Kraemer, W.J.
No effect of heavy resistance training and creatine supplementation on
blood lipids. International Journal of Sport Nutrition and Exercise
Metabolism 10 (2) 144-156 2000
Stone, M.H., Sanborn, K., Smith, L.L., O_Bryant, H.S., Hoke, T., Utter, A.C., Johnson,
R.L., Boros, R., Hruby, J., Pierce, K.C., Stone, M.E., Garner, B.
Effects of in-season (5 weeks) creatine and pyruvate supplementation on
anaerobic performance and body composition in American football players. International
Journal of Sport Nutrition 9 (2) 146-165 1999
Earnest, C.P., Almada, A.L., Mitchell, T.L.,
High-performance capillary electrophoresis-pure creatine monohydrate
reduces blood lipids in men and women. Clin Sci (Lond) 91 (1) 113-118
and Sport Nutrition Laboratory, Department of Human Movement Sciences and
Education, The University of Memphis, Memphis, TN, USA. Richard_Kreider@baylor.edu
Kreider, R.B., Melton, C., Rasmussen, C.J., Greenwood, M., Lancaster, S., Cantler, E.C.,
Milnor, P., Almada, A.L.
Long-term creatine supplementation does not significantly affect clinical
markers of health in athletes. Molecular and Cellular Biochemistry 244
(1-2) 95-104 2003
M.A., MacLennan, D.P.,
Creatine monohydrate supplementation enhances high-intensity exercise
performance in males and females. International Journal of Sport Nutrition
and Exercise Metabolism 10 (4) 452-463 2000
Kreider, R.B. Effects
of creatine supplementation on performance and training adaptations. Molecular
and Cellular Biochemistry 244 (1-2) 89-94 2003
Farquhar, W.B., Zambraski, E.J.,
Effects of creatine use on the athlete's kidney. Curr Sports Med Rep
1 (2) 103-106 2002
Prevost, M.C., Nelson, A.G., Morris, G.S.
Creatine supplementation enhances intermittent work performance. Research
Quarterly For Exercise and Sport 68 (3) 233-140 1997
Rossiter, H.B., Cannell, E.R., Jakeman, P.M.
The effect of oral creatine supplementation on the 1000-m performance of
competitive rowers. Journal of Sports Sciences 14 (2) 175-179 1996
G., Marsh, G.D., Casselman, M.A., Thompson, R.T.
Changes in human muscle transverse relaxation following short-term
creatine supplementation. Experimental Physiology 87 (3) 383-389 2002
Burke, L.M., Pyne, D.B., Telford, R.D.
Effect of oral creatine supplementation on single-effort sprint
performance in elite swimmers. International Journal of Sport Nutrition 6
(3) 222-233 1996
A.M., Atter, T., Georg, K.P.
Oral creatine supplementation improves multiple sprint performance in
elite ice-hockey players. The Journal of Sport Medicine and Physical Fitness
39 3 189-96 1999
D.M., Crowe, M.J.
Effects of beta-hydroxy-beta-methylbutyrate and creatine monohydrate
supplementation on the aerobic and anaerobic capacity of highly trained
athletes. The Journal of Sport Medicine and Physical Fitness 43 (1) 64-68
Redondo, D.R., Dowling, E.A., Graham, B.L., Almada, A.L., Williams, M.H.
The effect of oral creatine monohydrate supplementation on running
velocity. International Journal of Sport Nutrition 6 (3) 213-221 1996
Romer, L.M., Barrington, J.P., Jeukendrup, A.E.
Effects of oral creatine supplementation on high intensity, intermittent
exercise performance in competitive squash players. International Journal of
Sports Medicine 22 (8) 546-552 2001
Burke, D.G., Chilibeck, P.D., Davidson, K.S., Candow, D.G., Farthing, J., Smith_Palmer,
effect of whey protein supplementation with and without creatine monohydrate
combined with resistance training on lean tissue mass and muscle strength. International
Journal of Sport Nutrition and Exercise Metabolism 11 (3) 349-364 2001
M., Smith, P.M., Davison, R.C., Hughes, M.G.
Caffeine is ergogenic after supplementation of oral creatine monohydrate.
Medicine and Science in Sports and Exercise 34 (11) 1785-1792 2002
Kreider, R.B., Ferreira, M., Wilson, M., Grindstaff, P., Plisk, S., Reinardy, J., Cantler,
E., Almada, A.L.
Effects of creatine supplementation on body composition, strength, and
sprint performance. Medicine and Science in Sports and Exercise 30 (1)
Terrillion, K.A., Kolkhorst, F.W., Dolgener, F.A., Joslyn, S.J.
The effect of creatine supplementation on two 700-m maximal running
bouts. International Journal of Sport Nutrition 7 (2) 138-143 1997
Research Lab, Department of Health and Sport Sciences, University of Oklahoma,
Norman, OK 73019, USA. email@example.com
Tuttle, T.D., Bemben, D.A., Knehans, A.W.
Effects of creatine supplementation on isometric force-time curve
characteristics. Medicine and Science in Sports and Exercise 33 (11)
Urbanski, R.L., Vincent, W.J., Yaspelkis, B.B.
Creatine supplementation differentially affects maximal isometric
strength and time to fatigue in large and small muscle groups. International
Journal of Sport Nutrition 9 (2) 136-145 1999
Dalton, B., Tarr, J.
The effects of creatine supplementation on high-intensity exercise
performance in elite performers. Eur J Appl Physiol Occup Physiol 78 (3)
Mayhew, D.L., Mayhew, J.L., Ware, J.S.
Effects of long-term creatine supplementation on liver and kidney
functions in American college football players. International Journal of
Sport Nutrition and Exercise Metabolism 12 (4) 453-460 2002
Grindstaff, P.D., Kreider, R., Bishop, R., Wilson, M., Wood, L., Alexander, C., Almada, A.
Effects of creatine supplementation on repetitive sprint performance and
body composition in competitive swimmers. International Journal of Sport
Nutrition 7 (4) 330-346 1997
M.G., Bemben, D.A., Loftiss, D.D., Knehans, A.W.
Creatine supplementation during resistance training in college football
athletes. Medicine and Science in Sports and Exercise 33 (10) 1667-1673
Hamilton, K.L., Meyers, M.C., Skelly, W.A., Marley, R.J.
Oral creatine supplementation and upper extremity anaerobic response in
females. International Journal of Sport Nutrition and Exercise Metabolism 10
(3) 277-89 2000
M.S., Tarnopolsky, M.
Oral creatine supplementation and athletic performance: a critical
review. Clinical Journal of Sport Medicine : Official Journal of the Canadian
Academy of Sport Medicine 8 (4) 286-297 1998
Burke, D.G., Smith_Palmer, T., Holt, L.E., Head, B., Chilibeck, P.D.
The effect of 7 days of creatine supplementation on 24-hour urinary
creatine excretion. J Strength Cond Res 15 (1) 59-62 2001
B., Urso, B., Richter, E.A., Greenhaff, P.L., Hespel, P.
Effect of oral creatine supplementation on human muscle GLUT4 protein
content after immobilization. Diabetes 50 (1) 18-23 2001
Lawler, J.M., Barnes, W.S., Wu, G., Song, W., Demaree, S.
Direct antioxidant properties of creatine. Biochemical and Biophysical
Research Communications 290 (1) 47-52 2002
Vierck, J.L., Icenoggle, D.L., Bucci, L., Dodson, M.V.
The effects of ergogenic compounds on myogenic satellite cells. Medicine
and Science in Sports and Exercise 35 (5) 769-776 2003
Volek, J.S., Kraemer, W.J., Bush, J.A., Boetes, M., Incledon, T., Clark, K.L., Lynch,
Creatine supplementation enhances muscular performance during
high-intensity resistance exercise. Journal of the American Dietetic
Association 97 (7) 765-770 1997
A., Greenhaff, P.L.
Does dietary creatine supplementation play a role in skeletal muscle
metabolism and performance? The American Journal of Clinical Nutrition 72
(2 Suppl) 607S-617S 2000
M., Poortmans, J.R.,
Effects of training and creatine supplement on muscle strength and body
mass. Eur J Appl Physiol Occup Physiol 80 (2) 165-168 1999
R., Gramvik, P., Olsen, S.R., Jensen, J.
Creatine supplementation delays onset of fatigue during repeated bouts of
sprint running. Scandinavian Journal of Medicine & Science in Sports
8 (5 Pt 1) 247-251 1998
M., Malone, M., Justice, B., Trone, G., Pistilli, E., Vinci, D., Haff, E.E.,
Lon_Kilgore, J., Gregory_Haff, G.
The effects of 8 weeks of creatine monohydrate and glutamine
supplementation on body composition and performance measures. J Strength Cond
Res 17 (3) 425-438 2003
F., Vanden_Eynde, B., Vandenberghe, K., Hespel, P.
Effect of creatine loading on endurance capacity and sprint power in
cyclists. International Journal of Sports Medicine 19 (7) 490-495 1998
M., Parise, G., Fu, M.H., Brose, A., Parshad, A., Speer, O., Wallimann, T.
Acute and moderate-term creatine monohydrate supplementation does not
affect creatine transporter mRNA or protein content in either young or elderly
humans. Molecular and Cellular Biochemistry 244 (1-2) 159-166 2003
Dempsey, R.L., Mazzone, M.F., Meurer, L.N.
Does oral creatine supplementation improve strength? A meta-analysis. The
Journal of Family Practice 51 (11) 945-951 2002
I., Bleue, S., Goodman, J.
Creatine ingestion increases anaerobic capacity and maximum accumulated
oxygen deficit. Canadian Journal of Applied Physiology 22 (3) 231-243
I., Chatard, J.C., Lacoste, L., Barale, F., Geyssant, A.
Creatine supplementation does not improve sprint performance in
competitive swimmers. Medicine and Science in Sports and Exercise 28 (11)
M.A., Flanagan, T.R., Snow, R.J., Zhao, S., Carey, M.F.
Effect of creatine supplementation on intramuscular TCr, metabolism and
performance during intermittent, supramaximal exercise in humans. Acta
Physiologica Scandinavica 155 (4) 387-395 1995
G., Mujika, I., Tumilty, D., Burke, L.
Acute creatine supplementation and performance during a field test
simulating match play in elite female soccer players. International Journal
of Sport Nutrition and Exercise Metabolism 12 (1) 33-46 2002
B., Hespel, P.
Short-term creatine supplementation does not alter the hormonal response
to resistance training. Medicine and Science in Sports and Exercise 33
(3) 449-453 2001
R.J., Arsac, L.M., Thiaudiere, E., Canioni, P., Manier, G.
Effect of creatine supplementation on phosphocreatine resynthesis,
inorganic phosphate accumulation and pH during intermittent maximal exercise. Journal
of Sports Sciences 20 (5) 427-437 2002
G., Mihic, S., MacLennan, D., Yarasheski, K.E., Tarnopolsky, M.A.
Effects of acute creatine monohydrate supplementation on leucine kinetics
and mixed-muscle protein synthesis. Journal of Applied Physiology:
Respiratory, Environmental and Exercise Physiology 91 (3) 1041-1047 2001
E., Ostaszewski, P., Jank, M., Sacharuk, J., Zieniewicz, A., Wilczak, J., Nissen,
Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase
lean body mass and muscle strength during a weight-training program. Nutrition
(Burbank, Los Angeles County, Calif.) 17 (7-8) 558-566
Schilling, B.K., Stone, M.H., Utter, A., Kearney, J.T., Johnson, M., Coglianese, R., Smith,
L., O_Bryant, H.S., Fry, A.C., Starks, M., Keith, R., Stone, M.E.
Creatine supplementation and health variables: a retrospective study. Medicine
and Science in Sports and Exercise 33 (2) 183-188 2001
University, Columbus, Ohio 43209.
Biwer, C.J., Jensen, R.L., Schmidt, W.D., Watts, P.B.
The effect of creatine on treadmill running with high-intensity
intervals. J Strength Cond Res 17 (3) 439-445 2003
J.P., Tharion, W.J., Patton, J.F., Champagne, C.M., Mitotti, P., Lieberman, H.R.
The effect of creatine monohydrate supplementation on obstacle course and
multiple bench press performance. J Strength Cond Res 16 (4) 500-508 2002
V., Paasuke, M., Timpmann, S., Medijainen, L., Ereline, J., Gapejeva, J.
Effects of creatine supplementation during recovery from rapid body mass
reduction on metabolism and muscle performance capacity in well-trained
wrestlers. The Journal of Sport Medicine and Physical Fitness 42 (3)
Odland, L.M., MacDougall, J.D., Tarnopolsky, M.A., Elorriaga, A., Borgmann, A.
Effect of oral creatine supplementation on muscle [PCr] and short-term
maximum power output. Medicine and Science in Sports and Exercise 29 (2)
Arciero, P.J., Hannibal, N.S., Nindl, B.C., Gentile, C.L., Hamed, J., Vukovich, M.D.
Comparison of creatine ingestion and resistance training on energy
expenditure and limb blood flow. Metabolism: Clinical and Experimental 50
(12) 1429-1434 2001
P., Op_t_Eijnde, B., Van_Leemputte, M., Urso, B., Greenhaff, P.L., Labarque, V.,
Dymarkowski, S., Van_Hecke, P., Richter, E.A.
Oral creatine supplementation facilitates the rehabilitation of disuse
atrophy and alters the expression of muscle myogenic factors in humans. J
Physiol 536 (Pt 2) 625-633 2001
J.P., Ebert, T.R., Withers, R.T., Carey, M.F., Mackay, M., Phillips, J.W.,
Febbraio, M.A. Effect
of creatine supplementation on metabolism and performance in humans during
intermittent sprint cycling. European Journal of Applied Physiology and
Occupational Physiology 84 (3) 238-243 2001
N.M., Lamb, D.R., Nelson, T.E.
Creatine supplementation and swimming performance. International
Journal of Sport Nutrition 9 (3) 251-262 1999
D.A., McDonough, P.J., Fadel, P.J., Berwick, J.P.
Creatine supplementation and the total work performed during 15-s and
1-min bouts of maximal cycling. Australian Journal of Science and Medicine in
Sport 29 (3) 65-68 1997
C., Tihanyi, J., Pucspk, J., Kovacs, I., Gabossy, A., Colli, R., Pulvirenti, G.,
Tranquilli, C., Foti, C., Viru, M., Viru, A.
Effect of oral creatine supplementation on jumping and running
performance. International Journal of Sports Medicine 18 (5) 369-372 1997
Burke, D.G., Silver, S., Holt, L.E., Smith_Palmer, T., Culligan, C.J., Chilibeck, P.D.
The effect of continuous low dose creatine supplementation on force,
power, and total work. International Journal of Sport Nutrition and Exercise
Metabolism 10 (3) 235-244 2000
M.D., Lochmann, J.D., Melrose, D.R.
Effects of oral creatine supplementation on muscular strength and body
composition. Medicine and Science in Sports and Exercise 32 (3) 654-658
A., Kino, F., Kajitani, S., Sato, H., Fukuba, Y.
The effect of oral creatine supplementation on the curvature constant
parameter of the power-duration curve for cycle ergometry in humans. Japanese
Journal of Physiology 49 (2) 169-174 1999
R.J., McKenna, M.J., Selig, S.E., Kemp, J., Stathis, C.G., Zhao, S. Effect of creatine supplementation on sprint
exercise performance and muscle metabolism. Journal of Applied Physiology:
Respiratory, Environmental and Exercise Physiology 84 (5) 1667-1673 1998
Poortmans, J.R., Auquier, H., Renaut, V., Durussel, A., Saugy, M., Brisson, G.R.
Effect of short-term creatine supplementation on renal responses in men. Eur
J Appl Physiol Occup Physiol 76 (6) 566-567 1997
A., Constantin_Teodosiu, D., Howell, S., Hultman, E., Greenhaff, P.L.
Creatine ingestion favorably affects performance and muscle metabolism
during maximal exercise in humans. The American Journal of Physiology 271
(1 Pt 1) E31-E37 1996
B., Cutler, M., Moody, A., Lawrence, S., Goodman, C., Randall, N. Effects of oral creatine loading on single and
repeated maximal short sprints. Australian Journal of Science and Medicine in
Sport 27 (3) 56-61 1995
Syrotuik, D.G., Game, A.B., Gillies, E.M., Bell, G.J.
Effects of creatine monohydrate supplementation during combined strength
and high intensity rowing training on performance. Canadian Journal of
Applied Physiology 26 (6) 527-542 2001
S.W., Dudley, G.A., Creatine
loading, resistance exercise performance, and muscle mechanics. J Strength
Cond Res 15 (4) 413-419 2001
A.G., Day, R., Glickman_Weiss, E.L., Hegsted, M., Kokkonen, J., Sampson, B.
Creatine supplementation alters the response to a graded cycle ergometer
test. European Journal of Applied Physiology and Occupational Physiology
83 (1) 89-94 2000
J., Mendez_Marco, M.T. Creatine
enhances oxygen uptake and performance during alternating intensity exercise. Medicine
and Science in Sports and Exercise 32 (2) 379-385 2000
S., MacDonald, J.R., McKenzie, S., Tarnopolsky, M.A.
Acute creatine loading increases fat-free mass, but does not affect blood
pressure, plasma creatinine, or CK activity in men and women. Medicine and
Science in Sports and Exercise 32 (2) 291-296 2000
Brilla, L.R., Giroux, M.S., Taylor, A., Knutzen, K.M.
Magnesium-creatine supplementation effects on body water. Metabolism:
Clinical and Experimental 52 (9) 1136-1140 2003
C., Diels, R., Goris, M. Effect
of creatine supplementation on intermittent sprint running performance in highly
trained athletes. J Strength Cond Res 17 (3) 446-454 2003
D., Dawson, B., Goodman, C., Beilby, J., Ching, S.
Creatine supplementation: a comparison of loading and maintenance
protocols on creatine uptake by human skeletal muscle. International Journal
of Sport Nutrition and Exercise Metabolism 13 (1) 112-116 2003
Watsford, M.L., Murphy, A.J., Spinks, W.L., Walshe, A.D.
Creatine supplementation and its effect on musculotendinous stiffness and
performance. J Strength Cond Res 17 (1) 26-33 2003
A.M., Muller, M., Derendorf, H., Grant, M., Brazeau, G.A., Hochhaus, G.
Single- and multiple-dose pharmacokinetics of oral creatine. Journal
of Clinical Pharmacology 43 (1) 29-37 2003
M., Vandenberghe, K., Hespel, P.
Shortening of muscle relaxation time after creatine loading. Journal
of Applied Physiology: Respiratory, Environmental and Exercise Physiology 86
(3) 840-844 1999
Green, J.M., McLester, J.R., Smith, J.E., Mansfield, E.R.
The effects of creatine supplementation on repeated upper- and lower-body
Wingate performance. J Strength Cond Res 15 (1) 36-41 2001
Volek, J.S., Mazzetti, S.A., Farquhar, W.B., Barnes, B.R., Gomez, A.L., Kraemer, W.J.
Physiological responses to short-term exercise in the heat after creatine
loading. Medicine and Science in Sports and Exercise 33 (7) 1101-1108
Robinson, T.M., Sewell, D.A., Casey, A., Steenge, G., Greenhaff, P.L. Dietary creatine supplementation does not affect
some haematological indices, or indices of muscle damage and hepatic and renal
function. British Journal of Sports Medicine 34 (4) 284-8 2000
J., Eckerson, J., Ebersole, K., Moore, G., Perry, S., Housh, T., Bull, A.,
Cramer, J., Batheja, A. Effect
of creatine loading on neuromuscular fatigue threshold. Journal of Applied
Physiology: Respiratory, Environmental and Exercise Physiology 88 (1)
M., Koster, M., Kreis, R., Walker, G., Boesch, C., Hoppeler, H. Creatine supplementation--part I: performance,
clinical chemistry, and muscle volume. Medicine and Science in Sports and
Exercise 31 (12) 1763-1769 1999
Selsby, J.T., Beckett, K.D., Kern, M., Devor, S.T.
Swim Performance Following Creatine Supplementation in Division III
Athletes. J Strength Cond Res 17 (3) 421-424 2003
J.C., Stephens, D.P., Hall, E.L., Jackson, A.W., Earnest, C.P. Effect of oral creatine ingestion on parameters
of the work rate-time relationship and time to exhaustion in high-intensity
cycling. Eur J Appl Physiol Occup Physiol 77 (4) 360-365 1998
Schedel, J.M., Tanaka, H., Kiyonaga, A., Shindo, M., Schutz, Y.
Acute creatine loading enhances human growth hormone secretion. The
Journal of Sport Medicine and Physical Fitness 40 (4) 336-342 2000
Y., Hamaoka, T., Katsumura, T., Kuwamori, M., Kimura, N., Sako, T., Chance, B.
Creatine supplementation enhances anaerobic ATP synthesis during a single
10 sec maximal handgrip exercise. Molecular and Cellular Biochemistry 244
(1-2) 105-112 2003
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